Acute Kidney Injury (AKI) is a significant contributor to morbidity and mortality. A nationwide survey in China reported an in-hospital mortality rate of 12.4% for AKI patients but excluded the Xizang Autonomous Region [1]. With an average elevation above 4,000 meters, Xizang presents a unique environment with hypobaric hypoxia. In 2025, Chi-lie, et al. [2] published the first retrospective cohort analysis of AKI in the People’s Hospital of Xizang in Xizang Autonomous region, providing much-needed baseline data.